Kishori IVF


Diminished Ovarian Reserve or Low egg counts, What is it and how does it impact fertility?

Diminished Ovarian Reserve: What Is It?

A woman with a reduced ovarian reserve will produce fewer, lower-quality eggs from her ovaries, which will affect her ability to conceive and give birth. Women who wish to become pregnant face significant challenges due to this illness, particularly those who are 35 years of age or older.

Who could experience diminished ovarian reserve?

Because ovarian function naturally declines with age, women in their late 30s and early 40s are most commonly affected by diminished ovarian reserve. However, it can also appear in younger women as a result of different illnesses or medical interventions.

What Categories Does the Diminished Ovarian Reserve Fall Under?

There are three categories into which Diminished Ovarian Reserve falls:

  • Primary DOR: Caused by ageing naturally, it is linked to a decline in the number and calibre of eggs produced.
  • Secondary DOR: The consequences of medical treatments like radiation, chemotherapy, or surgery that change the way ovaries function.
  • Occult DOR: This condition, which is frequently identified during fertility evaluations, is typified by regular menstrual cycles despite diminished ovarian function.
Which elements are involved in the Diminished Ovarian Reserve?

Several factors lead to diminished ovarian reserve, including:

  • Age: As people age, their egg production naturally declines in quantity and quality.
  • Genetic Predisposition: Some individuals have genes from birth that increase their risk of developing ovarian failure as they age.
  • Medical Treatments: Radiation, chemotherapy, and ovarian surgery can all impair the ovaries’ ability to function.
  • Autoimmune Disorders: Certain autoimmune diseases may hurt ovarian function.
  • Smoking and substance abuse: These behaviours can accelerate the ageing of the ovarian reserve.
  • Environmental Toxins: Exposure to particular environmental toxins may also have an impact on DOR.
What Indices and Manifestations Are There in Reduced Ovarian Reserve?

At first, diminished ovarian reserve may show minimal or no symptoms. On the other hand, as the illness worsens, some signs might appear:

  • Irregular cycles of menstruation
  • Inability to conceive
  • reduced or nonexistent symptoms before menstruation
  • Reduced response to fertility treatments like in vitro fertilization (IVF)
Does Diminished Ovarian Reserve Impact Fertility?

Reduced Ovarian Reserve: This seriously reduces fertility. Conception becomes more difficult as a result of the lower quality and quantity of eggs, which decreases the chances of successful fertilization and implantation. It also increases the chance of chromosomal abnormalities in embryos and miscarriages.

How is Diminished Ovarian Reserve Diagnosed?

Several examinations and tests are required to diagnose diminished ovarian reserve:

  • Hormone testing: Blood tests to assess levels of the anti-Müllerian hormone (AMH), luteinising hormone (LH), follicle-stimulating hormone (FSH), and estradiol.
  • Antral Follicle Count: An ultrasonography procedure used to measure the number of tiny follicles in the ovaries, which is a measure of ovarian reserve.
  • Menstrual cycle regularity and levels of inhibin B, a hormone produced by developing ovarian follicles, are assessed as part of the ovarian reserve assessment process.
How is Diminished Ovarian Reserve Managed?

Although challenging to treat, several approaches can enhance fertility or facilitate conception:

  • In Vitro Fertilization (IVF): Stimulating the ovaries with fertility medications to retrieve multiple eggs for fertilization and implantation.
  • Egg Donation: Utilizing eggs from a healthy, young donor in an IVF cycle to increase the likelihood of successful conception.
  • Pre-implantation Genetic Testing: Screening embryos for chromosomal abnormalities before implantation to improve pregnancy outcomes.
  • Ovarian Rejuvenation Techniques: Experimental procedures aimed at enhancing ovarian function, albeit their efficacy and safety warrant further research.

Reduced Ovarian Reserve is a major obstacle for women who are trying to get pregnant. To manage this condition and investigate feasible conception routes, it is essential to comprehend its aetiology, manifestations, diagnosis, and available treatments. In the process of becoming a parent, seeking advice from fertility specialists and thinking through various treatment options can provide encouragement and hope.

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